Tretinoin Gel

Description

American Academy of Dermatology recommends topical tretinoin as a first-generation retinoid for hyperpigmentation, including melasma and post-inflammatory dark spots.

Tretinoin accelerates skin cell turnover and inhibits melanin transfer to keratinocytes, gradually lightening discolored areas over 12 to 40 weeks 1?. Clinical studies show 0.025% to 0.1% tretinoin gel improves mottled hyperpigmentation and lentigines in photodamaged skin

The US FDA approved tretinoin for acne and photoaging, but it is also used off-label for melasma and axillary hyperpigmentation. A 12-week trial found 0.025% tretinoin cream reduced axillary melanin index by 28% with minimal irritation 4. It is often combined with hydroquinone for enhanced results, though side effects include dryness and peeling

Dermatologists like C Dr. Shereene Idriss advise using tretinoin at night and daily sunscreen to prevent further pigmentation ® Results are slow and consistent use is required, with improvement typically visible after 24 weeks?